Pack size: 90 capsules

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Active Folate

Active Folate 800 mcg

56,99 zł

Supports maternal tissue growth during pregnancy
Helps maintain normal homocysteine metabolism
Supports blood formation, immune function, and cell division

Overview

Active folate, ready for the body's folate pathways. Designed for adults, especially women preparing for pregnancy or already pregnant, Active Folate uses Quatrefolic®, the patented glucosamine salt of active (6S)-5-methyltetrahydrofolate. This form does not require the prior conversion of inactive folic acid into 5-MTHF.

At the heart of the formula / Active Folate

Thoughtful support. Clear purpose.

01Supports maternal tissue growth during pregnancy
02Helps maintain normal homocysteine metabolism
03Supports blood formation, immune function, and cell division
04Helps reduce tiredness and fatigue
05A simple addition to a preconception routine

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Active Folate

Made for your daily routine.

Folate contributes to maternal tissue growth during pregnancy, normal blood formation, psychological function, and immune function. It also plays a role in cell division, amino acid synthesis, and homocysteine metabolism, and helps reduce tiredness and fatigue.

One capsule daily provides branded 5-MTHF at 200% of the EU Nutrient Reference Value (NRV), with a 90-day supply in each bottle. If you are planning a pregnancy, discuss your prenatal supplement plan with your clinician.

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Active Folate

Why choose an active form of folate?

Folate plays a role in cell division and supports normal blood formation, homocysteine metabolism, immune function, and psychological function. It also contributes to maternal tissue growth during pregnancy. This formula uses 5-MTHF, a biologically active form that does not require the same conversion steps as folic acid.

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Active Folate

What research informs Active Folate?

Clinical studies have shown that 5-MTHF can raise blood folate levels. Some trials in women of reproductive age reported greater increases in red blood cell or plasma folate than with equivalent amounts of folic acid. EFSA has also assessed the bioavailability of 5-MTHF salts. This research informed our choice of Quatrefolic®, a branded 5-MTHF source. Blood folate findings do not establish that this product prevents neural tube defects.

Ingredients / Doctor Life

Every ingredient. Clearly explained.

Each ingredient, its form and quantity — in one place.

Ingredient amounts for the servings shown in the table.
Ingredient	1 capsule
Folate (Quatrefolic®—glucosamine salt of (6S)-5-methyltetrahydrofolic acid)	800 µg
including folic acid	400 µg (200%*)

*NRV: Nutrient Reference Value

Full ingredient list

Bulking agent: cellulose; capsule shell (hydroxypropyl methylcellulose); folate (glucosamine salt of (6S)-5-methyltetrahydrofolic acid).

How to use

Part of your daily rhythm.

How to use

Adults, including pregnant women: take 1 capsule daily with a meal.

Important information

Do not exceed the recommended daily serving. Food supplements should not replace a varied diet. A balanced diet and a healthy lifestyle are recommended. Store in the original packaging, away from sunlight and out of reach of young children.

Science & sources

Understand the formula.

Folate has well-established roles in maternal tissue growth during pregnancy, cell division, blood formation, and homocysteine metabolism. Research on active 5-MTHF provides context for its use as an alternative to conventional folic acid, particularly for women who pay close attention to the form of their supplements.

These publications concern the studied ingredients or formulas. They do not all evaluate the finished Doctor Life product, and research results do not guarantee individual outcomes.

01Scientific Opinion on the substantiation of health claims related to folate and blood formation, homocysteine metabolism, cell division, and maternal tissue growth during pregnancy

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)

EFSA Journal (2009), 7(9), 1213. DOI: 10.2903/j.efsa.2009.1213.

EFSA experts confirmed folate's role in normal blood formation, homocysteine metabolism, cell division, and maternal tissue growth during pregnancy. These functions are particularly relevant before and during pregnancy. The publication concerns folate as a nutrient.

Read publication ↗

02Conversion of calcium-L-methylfolate and (6S)-5-methyltetrahydrofolic acid glucosamine salt into dietary folate equivalents

EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA)

EFSA Journal (2022), 20(8), 7452. DOI: 10.2903/j.efsa.2022.7452; PMID: 36034319.

This scientific opinion examines the same ingredient class used in this formula: the glucosamine salt of 5-MTHF. EFSA evaluated its conversion to dietary folate equivalents and reported greater bioavailability than folic acid at intakes of 400 mcg or more. The opinion provides context for choosing an active form in Active Folate.

Read publication ↗

03Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age

Yvonne Lamers, Reinhild Prinz-Langenohl, Susanne Brämswig, Klaus Pietrzik

The American Journal of Clinical Nutrition (2006), 84(1), 156-161. DOI: 10.1093/ajcn/84.1.156; PMID: 16825690.

A 24-week randomized study in 144 women of reproductive age compared 5-MTHF, folic acid, and placebo. An equimolar dose of 5-MTHF increased red blood cell folate concentrations more effectively than 400 mcg of folic acid. The study examined the general [6S]-5-MTHF form.

Read publication ↗

FAQ / Active Folate

Good questions. Clear answers.

Talk to us ↗

How does Quatrefolic® differ from folic acid?

Quatrefolic® is the glucosamine salt of (6S)-5-MTHF, a biologically active form of folate. Folic acid goes through additional conversion steps in the body. Both can contribute to folate intake; the appropriate form depends on your needs and professional advice.

When should I start supplementation before a planned pregnancy?

Discuss your prenatal supplement plan with your clinician before trying to conceive. Guidance on reducing neural tube defect risk concerns 400 mcg of folic acid daily, starting at least one month before conception and continuing through early pregnancy. Active Folate contains 5-MTHF, a different form, so do not assume it replaces a recommended folic acid supplement.

Can Active Folate be used during pregnancy?

The label recommends one capsule daily with a meal for adults, including pregnant women. Folate contributes to maternal tissue growth during pregnancy. Ask your clinician how this 5-MTHF supplement fits into your prenatal plan, particularly if you already take a prenatal vitamin.

Do MTHFR variants affect the choice of folate?

5-MTHF is an active form of folate. Studies have shown that it raises blood folate levels in people with the MTHFR variants studied. Common MTHFR variants do not mean you cannot process folic acid or should avoid it. Discuss genetic test results and prenatal supplement choices with your clinician.

Can I combine Active Folate with a prenatal vitamin or multivitamin?

Check every product for folate or folic acid and consider your total daily intake. Active Folate provides 200% of the EU Nutrient Reference Value (NRV). During pregnancy, medical treatment, or an individualized supplement plan, ask your doctor or pharmacist to review the combination.

How long does one bottle last?

Each bottle contains 90 capsules. Take one capsule daily with a meal for a 90-day supply.

Why does consistent folate intake matter?

Folate supports cell division, normal blood formation, and maternal tissue growth during pregnancy. If you are planning a pregnancy, arrange your prenatal supplement plan in advance and follow it consistently. A capsule taken with a regular meal can make the routine easier to remember.

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