Doctor Life Apigenin 50 mg — 90 capsules

Pack size: 90 capsules

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Apigenin 50 mg

Apigenin from grapefruit extract

65,99 zł

Targeted supplementation with one clearly defined flavonoid
An apigenin amount close to that assessed in a human pharmacokinetic study
An ingredient studied in relation to sleep quality and overnight recovery

Overview

Apigenin, in a clearly defined serving. This naturally occurring flavone is found in chamomile, parsley, celery, and citrus fruit. Apigenin 50 mg uses grapefruit extract and states the amount of apigenin itself, so you know exactly what the formula provides.

At the heart of the formula / Apigenin 50 mg

Thoughtful support. Clear purpose.

01Targeted supplementation with one clearly defined flavonoid
02An apigenin amount close to that assessed in a human pharmacokinetic study
03An ingredient studied in relation to sleep quality and overnight recovery
04An option for routines focused on healthy aging
05A simple formula that makes your supplement routine easier to understand
06A plant-derived ingredient in a pullulan capsule
07A defined apigenin content, rather than an unspecified extract blend

Doctor Life / 01

Apigenin 50 mg

Made for your daily routine.

A 2022 human pharmacokinetic study used a capsule containing approximately 51.6 mg of apigenin, close to the 50 mg in this formula. The study examined how apigenin is processed by the body, not whether it improves sleep.

Experimental apigenin research examines mechanisms including GABA-A receptors and CD38, an enzyme associated with NAD+ metabolism. Human research includes pharmacokinetics, oxidative balance markers, and observational sleep data. These findings are preliminary and do not establish the effects of this finished supplement.

This focused formula provides apigenin in a plant-based pullulan capsule, without added melatonin, magnesium, or sedative herbs. It makes the apigenin amount clear within your broader supplement routine.

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Apigenin 50 mg

Why is apigenin of interest?

Apigenin is a flavone, a type of polyphenol found in edible plants. Experimental studies examine GABA-A receptors, CD38/NAD+ pathways, and oxidative balance. Human evidence is most direct for pharmacokinetics and metabolism; observational studies also explore dietary intake and sleep quality. Associations and laboratory mechanisms do not establish a sleep benefit from supplementation.

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Apigenin 50 mg

What does research say about Apigenin 50 mg?

A human pharmacokinetic study used approximately 51.6 mg of apigenin in a capsule, close to this product’s 50 mg. An observational study of 1,936 adults associated higher dietary apigenin intake with better sleep quality. A dietary trial assessed antioxidant enzyme activity, and a 2024 review discussed sleep, NAD+ metabolism, and aging-related research. These studies do not demonstrate that isolated apigenin at 50 mg improves sleep.

Ingredients / Doctor Life

Every ingredient. Clearly explained.

Each ingredient, its form and quantity — in one place.

Ingredient amounts for the servings shown in the table.
Ingredient	1 capsule
Citrus paradisi extract	60 mg
of which apigenin	50 mg

*NRV: Nutrient Reference Value

Full ingredient list

Apigenin from grapefruit extract (Citrus paradisi), capsule shell (pullulan).

How to use

Part of your daily rhythm.

How to use

Take 1 capsule with a meal or 200 mL of water.

Important information

Do not exceed the recommended daily serving. Food supplements should not replace a varied diet. A balanced diet and a healthy lifestyle are recommended. Store at room temperature, away from sunlight and out of reach of young children.

Science & sources

Understand the formula.

The formula's closest research reference is a pharmacokinetic study of approximately 51.6 mg of apigenin in a capsule, similar to the 50 mg in this Doctor Life product. Other human studies examine associations between apigenin intake and sleep quality, and a randomized dietary study assessed enzymes involved in antioxidant protection.

These publications concern the studied ingredients or formulas. They do not all evaluate the finished Doctor Life product, and research results do not guarantee individual outcomes.

01Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults

Gina Borges, Reedmond Y. Fong, Jodi L. Ensunsa, Jennifer Kimball, Valentina Medici, Javier I. Ottaviani, Alan Crozier

Free Radical Biology and Medicine (2022), 185, 90-96. DOI: 10.1016/j.freeradbiomed.2022.04.007; PMID: 35452808.

In a clinical study, healthy men received a capsule containing 191 µmol of apigenin, approximately 51.6 mg, close to the amount in this Doctor Life product. Researchers tracked apigenin and its metabolites in plasma and urine, confirming conversion to characteristic glucuronides after oral intake. This provides a direct reference for isolated apigenin in a capsule at a similar amount.

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02Specific Dietary (Poly)phenols Are Associated with Sleep Quality in a Cohort of Italian Adults

Justyna Godos, Raffaele Ferri, Sabrina Castellano, Donato Angelino, Pedro Mena, Daniele Del Rio, Filippo Caraci, Fabio Galvano, Giuseppe Grosso

Nutrients (2020), 12(5), 1226. DOI: 10.3390/nu12051226; PMID: 32357534.

In a cohort of 1,936 adults, researchers assessed intake of individual polyphenols and sleep quality using the Pittsburgh Sleep Quality Index. Higher apigenin intake was significantly associated with a lower likelihood of poor sleep quality (OR 0.63; 95% CI 0.44–0.90). This observational finding helps explain the interest in apigenin for sleep, but does not establish cause and effect.

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03Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects

S. E. Nielsen, J. F. Young, B. Daneshvar, S. T. Lauridsen, P. Knuthsen, B. Sandström, L. O. Dragsted

British Journal of Nutrition (1999), 81(6), 447-455. DOI: 10.1017/S000711459900080X; PMID: 10615220.

In a randomized crossover study, 14 healthy adults followed either a controlled diet with apigenin-rich parsley or the baseline diet. During the apigenin-rich period, red blood cell superoxide dismutase (SOD) and glutathione reductase activity increased significantly. The study links dietary apigenin intake with measurable changes in antioxidant enzymes in humans.

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FAQ / Apigenin 50 mg

Good questions. Clear answers.

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Has an amount close to 50 mg been studied in humans?

Yes. A 2022 pharmacokinetic study gave participants 191 µmol of apigenin, approximately 51.6 mg, in a capsule. This is close to the 50 mg serving. The study examined pharmacokinetics, not sleep outcomes.

Is grapefruit-derived apigenin different from chamomile-derived apigenin?

Apigenin is chemically the same compound regardless of its plant source. The complete extracts can differ because they contain other compounds. This product states the amount of apigenin itself, rather than only the extract weight.

How can 60 mg of grapefruit extract provide 50 mg of apigenin?

The stated apigenin content is highly concentrated: approximately 83% of the extract’s weight. Both the total extract amount and apigenin amount are listed.

Is Apigenin 50 mg a proven sleep supplement?

Observational research links higher dietary apigenin intake with better sleep quality, but the cited evidence does not include a randomized trial of isolated 50 mg apigenin with sleep as its primary outcome. Mechanistic and pharmacokinetic findings do not establish a sleep benefit.

Do I have to take it in the evening?

No. The label does not specify a time or require bedtime use. Take 1 capsule with a meal or 200 mL of water, at a consistent time that fits your routine.

Does the grapefruit source matter if I take medication?

Grapefruit can interact with certain medicines, often because of compounds such as furanocoumarins. The label does not state their content in this extract. If your medication carries a grapefruit warning, consult your doctor or pharmacist before taking the supplement.

Why choose a defined apigenin amount instead of chamomile?

Chamomile contains many compounds, and its apigenin content varies by preparation. Apigenin 50 mg provides a clearly stated amount of one flavonoid, making it easier to track that ingredient in your routine.

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